Thesis (M.Sc.) -- University of Toronto, 1995.
|Series||Canadian theses = -- Thèses canadiennes|
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Molecular basis of chronic lymphocytic leukemia diagnosis and prognosis Specific chromosomal abnormalities and gene mutations may serve as diagnostic and prognostic indicators for disease progression and by: Molecular profiling has paved the way for the discovery of key pathways essential for the development and progression of acute lymphoblastic leukemia (ALL). This chapter summarizes advances in understanding of the genetic basis of ALL and therapy : Bela Patel, Fiona Fernando. First International Workshop on Chromosomes in Leukemia, , Chromosomes in acute nonlymphocytic leukaemia, Br. J. Haematol. – Google Scholar Fourth International Workshop on Chromosomes in Leukemia, , A prospective study of acute nonlymphocytic leukemia Cited by: Leukemia: Selected full-text books and articles Know the Facts about Leukemia and Lymphoma Nutrition Health Review, No. , Fall Read preview Overview.
Leukemia appears to result from a combination of factors, which can include genetic predisposition, chromosomal changes, chemical agents (benzene), chemotherapeutic agents, radiation, immunocompromise, and viruses. Although viruses have been tied to leukemias in animals, only adult T cell leukemia is known to result from a virus, human T cell. Learn from WebMD's slideshow about the common types and stages of leukemia, who gets it, symptoms, tests, treatments, and more. People with blood cancer are living longer than ever, and it . Chromosome 1p 1q 2 4 5 7 8 9 10 11 12 13 14 15 Copy Number homozygous deletion in part of chromosome 13 three copies of chromosome 12 trisomy 3 heterozygous deletion. Chronic myeloid leukemia is a slow-growing cancer of the blood-forming tissue (bone marrow). Normal bone marrow produces red blood cells (erythrocytes) that carry oxygen, white blood cells (leukocytes) that protect the body from infection, and platelets (thrombocytes) that are involved in blood clotting. Explore symptoms, inheritance, genetics of this condition.
An important aspect of leukemia biology is the elucidation of the spectrum of chromosomal abnormalities and molecular mutations that cooperate in the pathways leading to leukemogenesis. 6 To identify genetic changes that cooperate with PML-RARA in vivo, we performed spectral karyotyping analysis of leukemias arising in PML-RARA mice and mice expressing PML . Leukemia is a complex and heterogeneous group of disorders. Understanding the determinants of leukemia has been aided by advances in immunological techniques, which have helped to identify chromosomal abnormalities that have significance not only for classification of the different subtypes of leukemia, but also for prognosis and treatment. acute leukemia are miR and miRa & b. miRa/has tumor suppressor properties and are expressed in low amounts in CLL . Translocation between chromosomes 3 & 21 results in formation of RUNX1-EVI1. This chimeric gene contributes to transformation of myelodysplastic syndrome or chronic my-elogenous leukemia to its aggressive forms. Basis of diagnosis of acute leukemia In the WHO classification of acute leukemia (Jaffe, et al, ) the diagnosis is based on an arbitrary cut-off point of 20% blasts as a percentage of bone marrow total or non-erythroid cells or as a percentage of peripheral blood cells.